| DATE | OPPONENT | TIME (ET) | Location |
| Mon, Apr 6th, 2009 | Oakland | 09:05 PM | Angel Stadium of Anaheim |
| Tue, Apr 7th, 2009 | Oakland | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Apr 8th, 2009 | Oakland | 10:05 PM | Angel Stadium of Anaheim |
| Thu, Apr 9th, 2009 | Oakland | 10:25 PM | Angel Stadium of Anaheim |
| Fri, Apr 10th, 2009 | Boston | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Apr 11th, 2009 | Boston | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Apr 12th, 2009 | Boston | 03:35 PM | Angel Stadium of Anaheim |
| Tue, Apr 14th, 2009 | at Seattle | 06:40 PM | SAFECO Field |
| Wed, Apr 15th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Thu, Apr 16th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Fri, Apr 17th, 2009 | at Minnesota | 08:10 PM | Metrodome |
| Sat, Apr 18th, 2009 | at Minnesota | 07:10 PM | Metrodome |
| Sun, Apr 19th, 2009 | at Minnesota | 02:10 PM | Metrodome |
| Tue, Apr 21st, 2009 | Detroit | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Apr 22nd, 2009 | Detroit | 10:05 PM | Angel Stadium of Anaheim |
| Thu, Apr 23rd, 2009 | Detroit | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Apr 24th, 2009 | Seattle | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Apr 25th, 2009 | Seattle | 09:05 PM | Angel Stadium of Anaheim |
| Sun, Apr 26th, 2009 | Seattle | 03:35 PM | Angel Stadium of Anaheim |
| Tue, Apr 28th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Wed, Apr 29th, 2009 | at Baltimore | 12:35 PM | Oriole Park at Camden Yards |
| Thu, Apr 30th, 2009 | at NY_Yankees | 07:05 PM | Yankee Stadium |
| Fri, May 1st, 2009 | at NY_Yankees | 07:05 PM | Yankee Stadium |
| Sat, May 2nd, 2009 | at NY_Yankees | 01:05 PM | Yankee Stadium |
| Sun, May 3rd, 2009 | at NY_Yankees | 01:05 PM | Yankee Stadium |
| Mon, May 4th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Tue, May 5th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Wed, May 6th, 2009 | Toronto | 10:05 PM | Angel Stadium of Anaheim |
| Thu, May 7th, 2009 | Toronto | 10:05 PM | Angel Stadium of Anaheim |
| Fri, May 8th, 2009 | Kansas_City | 10:05 PM | Angel Stadium of Anaheim |
| Sat, May 9th, 2009 | Kansas_City | 09:05 PM | Angel Stadium of Anaheim |
| Sun, May 10th, 2009 | Kansas_City | 03:35 PM | Angel Stadium of Anaheim |
| Tue, May 12th, 2009 | Boston | 10:05 PM | Angel Stadium of Anaheim |
| Wed, May 13th, 2009 | Boston | 10:05 PM | Angel Stadium of Anaheim |
| Thu, May 14th, 2009 | Boston | 03:35 PM | Angel Stadium of Anaheim |
| Fri, May 15th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Sat, May 16th, 2009 | at Texas | 04:10 PM | Rangers Ballpark in Arlington |
| Sun, May 17th, 2009 | at Texas | 02:05 PM | Rangers Ballpark in Arlington |
| Mon, May 18th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Tue, May 19th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Wed, May 20th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Thu, May 21st, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Fri, May 22nd, 2009 | at Los_Angeles | 10:10 PM | Dodger Stadium |
| Sat, May 23rd, 2009 | at Los_Angeles | 10:10 PM | Dodger Stadium |
| Sun, May 24th, 2009 | at Los_Angeles | 04:10 PM | Dodger Stadium |
| Mon, May 25th, 2009 | Chicago_WSox | 09:05 PM | Angel Stadium of Anaheim |
| Tue, May 26th, 2009 | Chicago_WSox | 10:05 PM | Angel Stadium of Anaheim |
| Wed, May 27th, 2009 | Chicago_WSox | 10:05 PM | Angel Stadium of Anaheim |
| Fri, May 29th, 2009 | Seattle | 10:05 PM | Angel Stadium of Anaheim |
| Sat, May 30th, 2009 | Seattle | 09:05 PM | Angel Stadium of Anaheim |
| Sun, May 31st, 2009 | Seattle | 03:35 PM | Angel Stadium of Anaheim |
| Tue, Jun 2nd, 2009 | at Toronto | 07:07 PM | Rogers Centre |
| Wed, Jun 3rd, 2009 | at Toronto | 07:07 PM | Rogers Centre |
| Thu, Jun 4th, 2009 | at Toronto | 12:37 PM | Rogers Centre |
| Fri, Jun 5th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Sat, Jun 6th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Sun, Jun 7th, 2009 | at Detroit | 01:05 PM | Comerica Park |
| Tue, Jun 9th, 2009 | at Tampa_Bay | 07:08 PM | Tropicana Field |
| Wed, Jun 10th, 2009 | at Tampa_Bay | 07:08 PM | Tropicana Field |
| Thu, Jun 11th, 2009 | at Tampa_Bay | 07:08 PM | Tropicana Field |
| Fri, Jun 12th, 2009 | San_Diego | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jun 13th, 2009 | San_Diego | 09:05 PM | Angel Stadium of Anaheim |
| Sun, Jun 14th, 2009 | San_Diego | 03:35 PM | Angel Stadium of Anaheim |
| Mon, Jun 15th, 2009 | at San_Francisco | 10:15 PM | AT&T Park |
| Tue, Jun 16th, 2009 | at San_Francisco | 10:15 PM | AT&T Park |
| Wed, Jun 17th, 2009 | at San_Francisco | 03:45 PM | AT&T Park |
| Fri, Jun 19th, 2009 | Los_Angeles | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jun 20th, 2009 | Los_Angeles | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Jun 21st, 2009 | Los_Angeles | TBA | Angel Stadium of Anaheim |
| Mon, Jun 22nd, 2009 | Colorado | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Jun 23rd, 2009 | Colorado | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Jun 24th, 2009 | Colorado | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Jun 26th, 2009 | at Arizona | 09:40 PM | Chase Field |
| Sat, Jun 27th, 2009 | at Arizona | 04:10 PM | Chase Field |
| Sun, Jun 28th, 2009 | at Arizona | 04:10 PM | Chase Field |
| Mon, Jun 29th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Tue, Jun 30th, 2009 | at Texas | TBA | Rangers Ballpark in Arlington |
| Wed, Jul 1st, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Thu, Jul 2nd, 2009 | Baltimore | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Jul 3rd, 2009 | Baltimore | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jul 4th, 2009 | Baltimore | 09:05 PM | Angel Stadium of Anaheim |
| Sun, Jul 5th, 2009 | Baltimore | 03:35 PM | Angel Stadium of Anaheim |
| Mon, Jul 6th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Jul 7th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Jul 8th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Jul 10th, 2009 | NY_Yankees | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jul 11th, 2009 | NY_Yankees | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Jul 12th, 2009 | NY_Yankees | 03:35 PM | Angel Stadium of Anaheim |
| Thu, Jul 16th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Fri, Jul 17th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Sat, Jul 18th, 2009 | at Oakland | 09:05 PM | Oakland-Alameda County Coliseu |
| Sun, Jul 19th, 2009 | at Oakland | 04:05 PM | Oakland-Alameda County Coliseu |
| Mon, Jul 20th, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Tue, Jul 21st, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Wed, Jul 22nd, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Thu, Jul 23rd, 2009 | Minnesota | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Jul 24th, 2009 | Minnesota | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jul 25th, 2009 | Minnesota | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Jul 26th, 2009 | Minnesota | TBA | Angel Stadium of Anaheim |
| Mon, Jul 27th, 2009 | Cleveland | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Jul 28th, 2009 | Cleveland | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Jul 29th, 2009 | Cleveland | 03:35 PM | Angel Stadium of Anaheim |
| Fri, Jul 31st, 2009 | at Minnesota | 08:10 PM | Metrodome |
| Sat, Aug 1st, 2009 | at Minnesota | 07:10 PM | Metrodome |
| Sun, Aug 2nd, 2009 | at Minnesota | 02:10 PM | Metrodome |
| Tue, Aug 4th, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Wed, Aug 5th, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Thu, Aug 6th, 2009 | at Chicago_WSox | 02:05 PM | U.S. Cellular Field |
| Fri, Aug 7th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Aug 8th, 2009 | Texas | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Aug 9th, 2009 | Texas | TBA | Angel Stadium of Anaheim |
| Mon, Aug 10th, 2009 | Tampa_Bay | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Aug 11th, 2009 | Tampa_Bay | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Aug 12th, 2009 | Tampa_Bay | 03:35 PM | Angel Stadium of Anaheim |
| Fri, Aug 14th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Sat, Aug 15th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Sun, Aug 16th, 2009 | at Baltimore | 01:35 PM | Oriole Park at Camden Yards |
| Mon, Aug 17th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Tue, Aug 18th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Wed, Aug 19th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Thu, Aug 20th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Fri, Aug 21st, 2009 | at Toronto | 07:07 PM | Rogers Centre |
| Sat, Aug 22nd, 2009 | at Toronto | 01:07 PM | Rogers Centre |
| Sun, Aug 23rd, 2009 | at Toronto | 01:07 PM | Rogers Centre |
| Mon, Aug 24th, 2009 | Detroit | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Aug 25th, 2009 | Detroit | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Aug 26th, 2009 | Detroit | 03:35 PM | Angel Stadium of Anaheim |
| Fri, Aug 28th, 2009 | Oakland | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Aug 29th, 2009 | Oakland | 09:05 PM | Angel Stadium of Anaheim |
| Sun, Aug 30th, 2009 | Oakland | 03:35 PM | Angel Stadium of Anaheim |
| Mon, Aug 31st, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Tue, Sep 1st, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Wed, Sep 2nd, 2009 | at Seattle | 06:40 PM | SAFECO Field |
| Fri, Sep 4th, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Sat, Sep 5th, 2009 | at Kansas_City | 07:10 PM | Kauffman Stadium |
| Sun, Sep 6th, 2009 | at Kansas_City | 02:10 PM | Kauffman Stadium |
| Mon, Sep 7th, 2009 | at Kansas_City | 02:10 PM | Kauffman Stadium |
| Tue, Sep 8th, 2009 | Seattle | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Sep 9th, 2009 | Seattle | 10:05 PM | Angel Stadium of Anaheim |
| Thu, Sep 10th, 2009 | Seattle | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Sep 11th, 2009 | Chicago_WSox | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Sep 12th, 2009 | Chicago_WSox | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Sep 13th, 2009 | Chicago_WSox | TBA | Angel Stadium of Anaheim |
| Tue, Sep 15th, 2009 | at Boston | 07:10 PM | Fenway Park |
| Wed, Sep 16th, 2009 | at Boston | 07:10 PM | Fenway Park |
| Thu, Sep 17th, 2009 | at Boston | 07:10 PM | Fenway Park |
| Fri, Sep 18th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Sat, Sep 19th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Sun, Sep 20th, 2009 | at Texas | 03:05 PM | Rangers Ballpark in Arlington |
| Mon, Sep 21st, 2009 | NY_Yankees | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Sep 22nd, 2009 | NY_Yankees | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Sep 23rd, 2009 | NY_Yankees | 03:35 PM | Angel Stadium of Anaheim |
| Fri, Sep 25th, 2009 | Oakland | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Sep 26th, 2009 | Oakland | 09:05 PM | Angel Stadium of Anaheim |
| Sun, Sep 27th, 2009 | Oakland | 03:35 PM | Angel Stadium of Anaheim |
| Mon, Sep 28th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Tue, Sep 29th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Wed, Sep 30th, 2009 | Texas | 10:05 PM | Angel Stadium of Anaheim |
| Thu, Oct 1st, 2009 | Texas | 06:05 PM | Angel Stadium of Anaheim |
| Fri, Oct 2nd, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Sat, Oct 3rd, 2009 | at Oakland | 04:05 PM | Oakland-Alameda County Coliseu |
| Sun, Oct 4th, 2009 | at Oakland | 04:05 PM | Oakland-Alameda County Coliseu |