| DATE | OPPONENT | TIME (ET) | Location |
| Mon, Apr 6th, 2009 | Seattle | 08:10 PM | Metrodome |
| Tue, Apr 7th, 2009 | Seattle | 08:10 PM | Metrodome |
| Wed, Apr 8th, 2009 | Seattle | 08:10 PM | Metrodome |
| Thu, Apr 9th, 2009 | Seattle | 01:10 PM | Metrodome |
| Fri, Apr 10th, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Sat, Apr 11th, 2009 | at Chicago_WSox | 04:10 PM | U.S. Cellular Field |
| Sun, Apr 12th, 2009 | at Chicago_WSox | 02:05 PM | U.S. Cellular Field |
| Mon, Apr 13th, 2009 | Toronto | 08:10 PM | Metrodome |
| Tue, Apr 14th, 2009 | Toronto | 08:10 PM | Metrodome |
| Wed, Apr 15th, 2009 | Toronto | 08:10 PM | Metrodome |
| Thu, Apr 16th, 2009 | Toronto | 08:10 PM | Metrodome |
| Fri, Apr 17th, 2009 | LA_Angels | 08:10 PM | Metrodome |
| Sat, Apr 18th, 2009 | LA_Angels | 07:10 PM | Metrodome |
| Sun, Apr 19th, 2009 | LA_Angels | 02:10 PM | Metrodome |
| Tue, Apr 21st, 2009 | at Boston | 07:10 PM | Fenway Park |
| Wed, Apr 22nd, 2009 | at Boston | 07:10 PM | Fenway Park |
| Wed, Apr 22nd, 2009 | at Boston | 12:35 PM | Fenway Park |
| Fri, Apr 24th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Sat, Apr 25th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Sun, Apr 26th, 2009 | at Cleveland | 01:05 PM | Progressive Field |
| Mon, Apr 27th, 2009 | Tampa_Bay | 08:10 PM | Metrodome |
| Tue, Apr 28th, 2009 | Tampa_Bay | 08:10 PM | Metrodome |
| Wed, Apr 29th, 2009 | Tampa_Bay | 08:10 PM | Metrodome |
| Fri, May 1st, 2009 | Kansas_City | 08:10 PM | Metrodome |
| Sat, May 2nd, 2009 | Kansas_City | 07:10 PM | Metrodome |
| Sun, May 3rd, 2009 | Kansas_City | 02:10 PM | Metrodome |
| Mon, May 4th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Tue, May 5th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Wed, May 6th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Thu, May 7th, 2009 | at Baltimore | 07:05 PM | Oriole Park at Camden Yards |
| Fri, May 8th, 2009 | Seattle | 08:10 PM | Metrodome |
| Sat, May 9th, 2009 | Seattle | 07:10 PM | Metrodome |
| Sun, May 10th, 2009 | Seattle | 02:10 PM | Metrodome |
| Tue, May 12th, 2009 | Detroit | 08:10 PM | Metrodome |
| Wed, May 13th, 2009 | Detroit | 08:10 PM | Metrodome |
| Thu, May 14th, 2009 | Detroit | 01:10 PM | Metrodome |
| Fri, May 15th, 2009 | at NY_Yankees | 07:05 PM | Yankee Stadium |
| Sat, May 16th, 2009 | at NY_Yankees | 01:05 PM | Yankee Stadium |
| Sun, May 17th, 2009 | at NY_Yankees | 01:05 PM | Yankee Stadium |
| Mon, May 18th, 2009 | at NY_Yankees | 07:05 PM | Yankee Stadium |
| Tue, May 19th, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Wed, May 20th, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Thu, May 21st, 2009 | at Chicago_WSox | 02:05 PM | U.S. Cellular Field |
| Fri, May 22nd, 2009 | Milwaukee | 08:10 PM | Metrodome |
| Sat, May 23rd, 2009 | Milwaukee | 07:10 PM | Metrodome |
| Sun, May 24th, 2009 | Milwaukee | 08:05 PM | Metrodome |
| Mon, May 25th, 2009 | Boston | 02:10 PM | Metrodome |
| Tue, May 26th, 2009 | Boston | 08:10 PM | Metrodome |
| Wed, May 27th, 2009 | Boston | 08:10 PM | Metrodome |
| Thu, May 28th, 2009 | Boston | 01:10 PM | Metrodome |
| Fri, May 29th, 2009 | at Tampa_Bay | 07:38 PM | Tropicana Field |
| Sat, May 30th, 2009 | at Tampa_Bay | 04:10 PM | Tropicana Field |
| Sun, May 31st, 2009 | at Tampa_Bay | 01:38 PM | Tropicana Field |
| Tue, Jun 2nd, 2009 | Cleveland | 08:10 PM | Metrodome |
| Wed, Jun 3rd, 2009 | Cleveland | 08:10 PM | Metrodome |
| Thu, Jun 4th, 2009 | Cleveland | 01:10 PM | Metrodome |
| Fri, Jun 5th, 2009 | at Seattle | 10:10 PM | SAFECO Field |
| Sat, Jun 6th, 2009 | at Seattle | 04:10 PM | SAFECO Field |
| Sun, Jun 7th, 2009 | at Seattle | 04:10 PM | SAFECO Field |
| Mon, Jun 8th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Tue, Jun 9th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Wed, Jun 10th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Thu, Jun 11th, 2009 | at Oakland | 03:35 PM | Oakland-Alameda County Coliseu |
| Fri, Jun 12th, 2009 | at Chicago_Cubs | 02:20 PM | Wrigley Field |
| Sat, Jun 13th, 2009 | at Chicago_Cubs | 01:05 PM | Wrigley Field |
| Sun, Jun 14th, 2009 | at Chicago_Cubs | 02:20 PM | Wrigley Field |
| Tue, Jun 16th, 2009 | Pittsburgh | 08:10 PM | Metrodome |
| Wed, Jun 17th, 2009 | Pittsburgh | 08:10 PM | Metrodome |
| Thu, Jun 18th, 2009 | Pittsburgh | 01:10 PM | Metrodome |
| Fri, Jun 19th, 2009 | Houston | 08:10 PM | Metrodome |
| Sat, Jun 20th, 2009 | Houston | 07:10 PM | Metrodome |
| Sun, Jun 21st, 2009 | Houston | 02:10 PM | Metrodome |
| Tue, Jun 23rd, 2009 | at Milwaukee | 08:05 PM | Miller Park |
| Wed, Jun 24th, 2009 | at Milwaukee | 08:05 PM | Miller Park |
| Thu, Jun 25th, 2009 | at Milwaukee | 02:05 PM | Miller Park |
| Fri, Jun 26th, 2009 | at St._Louis | 08:15 PM | Busch Stadium |
| Sat, Jun 27th, 2009 | at St._Louis | 01:10 PM | Busch Stadium |
| Sun, Jun 28th, 2009 | at St._Louis | 02:15 PM | Busch Stadium |
| Mon, Jun 29th, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Tue, Jun 30th, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Wed, Jul 1st, 2009 | at Kansas_City | 02:10 PM | Kauffman Stadium |
| Fri, Jul 3rd, 2009 | Detroit | 08:10 PM | Metrodome |
| Sat, Jul 4th, 2009 | Detroit | 04:10 PM | Metrodome |
| Sun, Jul 5th, 2009 | Detroit | 02:10 PM | Metrodome |
| Tue, Jul 7th, 2009 | NY_Yankees | 08:10 PM | Metrodome |
| Wed, Jul 8th, 2009 | NY_Yankees | 08:10 PM | Metrodome |
| Thu, Jul 9th, 2009 | NY_Yankees | 01:10 PM | Metrodome |
| Fri, Jul 10th, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Sat, Jul 11th, 2009 | Chicago_WSox | 07:10 PM | Metrodome |
| Sun, Jul 12th, 2009 | Chicago_WSox | 02:10 PM | Metrodome |
| Fri, Jul 17th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Sat, Jul 18th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Sun, Jul 19th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Mon, Jul 20th, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Tue, Jul 21st, 2009 | at Oakland | 10:05 PM | Oakland-Alameda County Coliseu |
| Wed, Jul 22nd, 2009 | at Oakland | 03:35 PM | Oakland-Alameda County Coliseu |
| Thu, Jul 23rd, 2009 | at LA_Angels | 10:05 PM | Angel Stadium of Anaheim |
| Fri, Jul 24th, 2009 | at LA_Angels | 10:05 PM | Angel Stadium of Anaheim |
| Sat, Jul 25th, 2009 | at LA_Angels | 04:10 PM | Angel Stadium of Anaheim |
| Sun, Jul 26th, 2009 | at LA_Angels | TBA | Angel Stadium of Anaheim |
| Mon, Jul 27th, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Tue, Jul 28th, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Wed, Jul 29th, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Fri, Jul 31st, 2009 | LA_Angels | 08:10 PM | Metrodome |
| Sat, Aug 1st, 2009 | LA_Angels | 07:10 PM | Metrodome |
| Sun, Aug 2nd, 2009 | LA_Angels | 02:10 PM | Metrodome |
| Tue, Aug 4th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Wed, Aug 5th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Thu, Aug 6th, 2009 | at Cleveland | 12:05 PM | Progressive Field |
| Fri, Aug 7th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Sat, Aug 8th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Sun, Aug 9th, 2009 | at Detroit | 01:05 PM | Comerica Park |
| Tue, Aug 11th, 2009 | Kansas_City | 08:10 PM | Metrodome |
| Wed, Aug 12th, 2009 | Kansas_City | 08:10 PM | Metrodome |
| Thu, Aug 13th, 2009 | Kansas_City | 01:10 PM | Metrodome |
| Fri, Aug 14th, 2009 | Cleveland | 08:10 PM | Metrodome |
| Sat, Aug 15th, 2009 | Cleveland | 04:10 PM | Metrodome |
| Sun, Aug 16th, 2009 | Cleveland | 02:10 PM | Metrodome |
| Mon, Aug 17th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Tue, Aug 18th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Wed, Aug 19th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Thu, Aug 20th, 2009 | at Texas | 08:05 PM | Rangers Ballpark in Arlington |
| Fri, Aug 21st, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Sat, Aug 22nd, 2009 | at Kansas_City | 07:10 PM | Kauffman Stadium |
| Sun, Aug 23rd, 2009 | at Kansas_City | 02:10 PM | Kauffman Stadium |
| Mon, Aug 24th, 2009 | Baltimore | 08:10 PM | Metrodome |
| Tue, Aug 25th, 2009 | Baltimore | 08:10 PM | Metrodome |
| Wed, Aug 26th, 2009 | Baltimore | 08:10 PM | Metrodome |
| Fri, Aug 28th, 2009 | Texas | 08:10 PM | Metrodome |
| Sat, Aug 29th, 2009 | Texas | 07:10 PM | Metrodome |
| Sun, Aug 30th, 2009 | Texas | 02:10 PM | Metrodome |
| Mon, Aug 31st, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Tue, Sep 1st, 2009 | Chicago_WSox | 08:10 PM | Metrodome |
| Wed, Sep 2nd, 2009 | Chicago_WSox | 01:10 PM | Metrodome |
| Fri, Sep 4th, 2009 | at Cleveland | 07:05 PM | Progressive Field |
| Sat, Sep 5th, 2009 | at Cleveland | 04:10 PM | Progressive Field |
| Sun, Sep 6th, 2009 | at Cleveland | 01:05 PM | Progressive Field |
| Mon, Sep 7th, 2009 | at Toronto | 01:07 PM | Rogers Centre |
| Tue, Sep 8th, 2009 | at Toronto | 07:07 PM | Rogers Centre |
| Wed, Sep 9th, 2009 | at Toronto | 07:07 PM | Rogers Centre |
| Thu, Sep 10th, 2009 | at Toronto | 12:37 PM | Rogers Centre |
| Fri, Sep 11th, 2009 | Oakland | 08:10 PM | Metrodome |
| Sat, Sep 12th, 2009 | Oakland | 08:10 PM | Metrodome |
| Sun, Sep 13th, 2009 | Oakland | 02:10 PM | Metrodome |
| Mon, Sep 14th, 2009 | Cleveland | 08:10 PM | Metrodome |
| Tue, Sep 15th, 2009 | Cleveland | 08:10 PM | Metrodome |
| Wed, Sep 16th, 2009 | Cleveland | 01:10 PM | Metrodome |
| Fri, Sep 18th, 2009 | Detroit | 08:10 PM | Metrodome |
| Sat, Sep 19th, 2009 | Detroit | 04:10 PM | Metrodome |
| Sun, Sep 20th, 2009 | Detroit | 02:10 PM | Metrodome |
| Mon, Sep 21st, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Tue, Sep 22nd, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Wed, Sep 23rd, 2009 | at Chicago_WSox | 08:11 PM | U.S. Cellular Field |
| Fri, Sep 25th, 2009 | at Kansas_City | 08:10 PM | Kauffman Stadium |
| Sat, Sep 26th, 2009 | at Kansas_City | 07:10 PM | Kauffman Stadium |
| Sun, Sep 27th, 2009 | at Kansas_City | 02:10 PM | Kauffman Stadium |
| Mon, Sep 28th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Tue, Sep 29th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Wed, Sep 30th, 2009 | at Detroit | 07:05 PM | Comerica Park |
| Thu, Oct 1st, 2009 | at Detroit | 01:05 PM | Comerica Park |
| Fri, Oct 2nd, 2009 | Kansas_City | 08:10 PM | Metrodome |
| Sat, Oct 3rd, 2009 | Kansas_City | 07:10 PM | Metrodome |
| Sun, Oct 4th, 2009 | Kansas_City | 02:10 PM | Metrodome |