| WEEK | DATE | OPPONENT | TIME (ET) | Location |
| Pre | Fri, Aug 14th, 2009 | at San_Francisco | 10:00 PM | Candlestick Park |
| Pre | Sat, Aug 22nd, 2009 | at Seattle | 10:30 PM | Qwest Field |
| Pre | Sun, Aug 30th, 2009 | Chicago | 08:00 PM | Invesco Field at Mile High |
| Pre | Thu, Sep 3rd, 2009 | Arizona | 09:00 PM | Invesco Field at Mile High |
| 1 | Sun, Sep 13th, 2009 | at Cincinnati | 01:00 PM | Paul Brown Stadium |
| 2 | Sun, Sep 20th, 2009 | Cleveland | 04:15 PM | Invesco Field at Mile High |
| 3 | Sun, Sep 27th, 2009 | at Oakland | 04:15 PM | Oakland Coliseum |
| 4 | Sun, Oct 4th, 2009 | Dallas | 04:15 PM | Invesco Field at Mile High |
| 5 | Sun, Oct 11th, 2009 | New_England | 04:15 PM | Invesco Field at Mile High |
| 6 | Mon, Oct 19th, 2009 | at San_Diego | 08:20 PM | Qualcomm Stadium |
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| 8 | Sun, Nov 1st, 2009 | at Baltimore | 01:00 PM | M&T Bank Stadium |
| 9 | Mon, Nov 9th, 2009 | Pittsburgh | 08:30 PM | Invesco Field at Mile High |
| 10 | Sun, Nov 15th, 2009 | at Washington | 01:00 PM | FedEx Field |
| 11 | Sun, Nov 22nd, 2009 | San_Diego | 04:15 PM | Invesco Field at Mile High |
| 12 | Thu, Nov 26th, 2009 | NY_Giants | 08:20 PM | Invesco Field at Mile High |
| 13 | Sun, Dec 6th, 2009 | at Kansas_City | 01:00 PM | Arrowhead Stadium |
| 14 | Sun, Dec 13th, 2009 | at Indianapolis | 01:00 PM | Lucas Oil Stadium |
| 15 | Sun, Dec 20th, 2009 | Oakland | 04:05 PM | Invesco Field at Mile High |
| 16 | Sun, Dec 27th, 2009 | at Philadelphia | 01:00 PM | Lincoln Financial Field |
| 17 | Sun, Jan 3rd, 2010 | Kansas_City | 04:15 PM | Invesco Field at Mile High |