| WEEK | DATE | OPPONENT | TIME (ET) | Location |
| Pre | Sat, Aug 15th, 2009 | Houston | 08:00 PM | Arrowhead Stadium |
| Pre | Fri, Aug 21st, 2009 | at Minnesota | 08:00 PM | Hubert H. Humphrey Metrodome |
| Pre | Sat, Aug 29th, 2009 | Seattle | 08:00 PM | Arrowhead Stadium |
| Pre | Thu, Sep 3rd, 2009 | at St._Louis | 08:00 PM | Edward Jones Dome |
| 1 | Sun, Sep 13th, 2009 | at Baltimore | 01:00 PM | M&T Bank Stadium |
| 2 | Sun, Sep 20th, 2009 | Oakland | 01:00 PM | Arrowhead Stadium |
| 3 | Sun, Sep 27th, 2009 | at Philadelphia | 01:00 PM | Lincoln Financial Field |
| 4 | Sun, Oct 4th, 2009 | NY_Giants | 01:00 PM | Arrowhead Stadium |
| 5 | Sun, Oct 11th, 2009 | Dallas | 01:00 PM | Arrowhead Stadium |
| 6 | Sun, Oct 18th, 2009 | at Washington | 01:00 PM | FedEx Field |
| 7 | Sun, Oct 25th, 2009 | San_Diego | 01:00 PM | Arrowhead Stadium |
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| 9 | Sun, Nov 8th, 2009 | at Jacksonville | 01:00 PM | Jacksonville Municipal Stadium |
| 10 | Sun, Nov 15th, 2009 | at Oakland | 04:05 PM | Oakland Coliseum |
| 11 | Sun, Nov 22nd, 2009 | Pittsburgh | 01:00 PM | Arrowhead Stadium |
| 12 | Sun, Nov 29th, 2009 | at San_Diego | 04:05 PM | Qualcomm Stadium |
| 13 | Sun, Dec 6th, 2009 | Denver | 01:00 PM | Arrowhead Stadium |
| 14 | Sun, Dec 13th, 2009 | Buffalo | 01:00 PM | Arrowhead Stadium |
| 15 | Sun, Dec 20th, 2009 | Cleveland | 01:00 PM | Arrowhead Stadium |
| 16 | Sun, Dec 27th, 2009 | at Cincinnati | 01:00 PM | Paul Brown Stadium |
| 17 | Sun, Jan 3rd, 2010 | at Denver | 04:15 PM | Invesco Field at Mile High |