| WEEK | DATE | OPPONENT | TIME (ET) | Location |
| Pre | Fri, Aug 14th, 2009 | at Indianapolis | 07:30 PM | Lucas Oil Stadium |
| Pre | Fri, Aug 21st, 2009 | Kansas_City | 08:00 PM | Hubert H. Humphrey Metrodome |
| Pre | Mon, Aug 31st, 2009 | at Houston | 08:00 PM | Reliant Stadium |
| Pre | Fri, Sep 4th, 2009 | Dallas | 08:00 PM | Hubert H. Humphrey Metrodome |
| 1 | Sun, Sep 13th, 2009 | at Cleveland | 01:00 PM | Cleveland Browns Stadium |
| 2 | Sun, Sep 20th, 2009 | at Detroit | 01:00 PM | Ford Field |
| 3 | Sun, Sep 27th, 2009 | San_Francisco | 01:00 PM | Hubert H. Humphrey Metrodome |
| 4 | Mon, Oct 5th, 2009 | Green_Bay | 08:20 PM | Hubert H. Humphrey Metrodome |
| 5 | Sun, Oct 11th, 2009 | at St._Louis | 01:00 PM | Edward Jones Dome |
| 6 | Sun, Oct 18th, 2009 | Baltimore | 01:00 PM | Hubert H. Humphrey Metrodome |
| 7 | Sun, Oct 25th, 2009 | at Pittsburgh | 01:00 PM | Heinz Field |
| 8 | Sun, Nov 1st, 2009 | at Green_Bay | 01:00 PM | Lambeau Field |
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| 10 | Sun, Nov 15th, 2009 | Detroit | 01:00 PM | Hubert H. Humphrey Metrodome |
| 11 | Sun, Nov 22nd, 2009 | Seattle | 01:00 PM | Hubert H. Humphrey Metrodome |
| 12 | Sun, Nov 29th, 2009 | Chicago | 01:00 PM | Hubert H. Humphrey Metrodome |
| 13 | Sun, Dec 6th, 2009 | at Arizona | 04:15 PM | University of Phoenix Stadium |
| 14 | Sun, Dec 13th, 2009 | Cincinnati | 01:00 PM | Hubert H. Humphrey Metrodome |
| 15 | Sun, Dec 20th, 2009 | at Carolina | 08:20 PM | Bank of America Stadium |
| 16 | Mon, Dec 28th, 2009 | at Chicago | 08:20 PM | Soldier Field |
| 17 | Sun, Jan 3rd, 2010 | NY_Giants | 01:00 PM | Hubert H. Humphrey Metrodome |